|
KMID : 0370220150590030085
|
|
Yakhak Hoeji
2015 Volume.59 No. 3 p.85 ~ p.90
|
|
|
Pharmacokinetic Study of Matrine in SD-rat after Oral Administration of KIOM-MA128
|
|
Lee Jae-Yeon
Back Hyun-Moon
Song Byung-Jeong
Chae Jung-Woo
Jung Seong-Mee
Pradhan Sudeep
Yun Hwi-Yeol
Kwon Kwang-II
|
|
|
Abstract
|
|
|
|
KIOM-MA128 is a novel Korean herbal medicine with anti-atopic, anti-inflammatory and anti-asthmatic effects. This article presents the first pharmacokinetic study on KIOM-MA128. The purpose of this study was to characterize a pharmacokinetic characteristic of matrine, a potential marker of KIOM-MA128, in rats using population pharmacokinetic model. 1, 2 and 8 g/kg of KIOM-MA128 were administered to rats orally and plasma concentrations of matrine was determined by HPLC-MS/MS. Non-compartmental analysis (NCA) was performed using Phoenix® and pharmacokinetic model was built using NONMEM®. This model was validated with internal validation which is visual predictive check (VPC) and bootstrap. The NCA result of matrine showed that Cmax was 294.24, 552.22 and 868.65 ng/ml, AUCinf was 1273.05, 2724.76 and 9743.25 ng · hr/ml and Tmax was 1, 1.3 and 2.3 hr for the doses of 1, 2, and 8 g/kg, respectively. The rat plasma concentrations were described very well with one-compartment model. Pharmacokinetic model for matrine was successfully developed and evaluated. Finally, our model is helpful to understand pharmacokinetic characteristic of KIOM-MA128.
|
|
|
KEYWORD
|
|
|
KIOM-MA128, pharmacokinetics, NONMEM, matrine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|